Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs
نویسندگان
چکیده
منابع مشابه
Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult animals using delivery routes with the most clinical relevance (intravenous or intrathecal). Here, we demonstrate that the spinal pia membrane repre...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2011
ISSN: 0969-7128,1476-5462
DOI: 10.1038/gt.2011.130